New Health Canada Data on Bisphenol A (BPA) Strongly Supports Safety of Bottled-Water, Baby-Food and Infant-Formula Products

Who We Are

This web site is sponsored by the Polycarbonate/BPA Global Group, which is organized regionally at the American Chemistry Council,PlasticsEurope, and the Japan Chemical Industry Association.

Bisphenol A (BPA) Information, Research & News

http://www.bisphenol-a.org/whatsNew/20090709.html

July 9, 2009

The following statement can be attributed to Steven G. Hentges, Ph.D. of the American Chemistry Council’s (ACC) Polycarbonate/BPA Global Group. Dr. Hentges’ comments are in regard to the recently released reports from Health Canada on its survey of bisphenol A (BPA) in bottled water, baby food, and infant formula products.

ARLINGTON, VA (July 9, 2009) —“Reports released today by Health Canada on research conducted by its scientists confirm that the levels of bisphenol A (BPA) in bottled water, baby food and infant formula are extremely low. These new government data confirm Health Canada’s previous conclusion that exposure to BPA through food packaging uses is not expected to pose a health risk to the general population, including newborns and young children.

“As noted by Health Canada, an adult would have to drink approximately 1,000 liters (or 264 gallons) of water from polycarbonate water cooler bottles every day to approach the science-based safe intake limit for BPA recently established in Canada.

“No BPA was detected in any of the canned powdered infant formula samples tested. The level of BPA found in baby food packaged in jars clearly indicates that exposure to BPA through consumption of these products is extremely low. Health Canada noted that the nutritional benefits of baby food products far outweigh any possible risk.

“Health Canada’s new data provides further support for recent assessments from eleven regulatory bodies around the world that determined BPA is safe for use in food contact products. These regulatory bodies include: the European Food Safety Authority, German Federal Institute for Risk Assessment, Danish Environmental Protection Agency, French Food Safety Authority, Swiss Office for Public Health, and Food Standards Australia-New Zealand.

“Polycarbonate plastic and epoxy resins, both made from BPA, are widely used in food packaging to protect the safety and integrity of foods and beverages. Clear, shatter-resistant polycarbonate water cooler bottles are also lightweight and reusable over many cycles. Epoxy resin coatings prevent corrosion of metal cans and lids and contamination of foods and beverages. ACC and its member companies have long-supported research to advance scientific understanding about chemicals, and we are committed to providing the compounds and plastics integral to products that help protect public health and safety.”

Survey of Bisphenol A in Baby Food Products Prepackaged in Glass Jars
http://www.hc-sc.gc.ca/fn-an/pubs/securit/bpa_survey-enquete-eng.php

Survey of Bisphenol A in Canned Powdered Infant Formula Products
http://www.hc-sc.gc.ca/fn-an/pubs/securit/bpa_survey-enquete-pow-pou-eng.php

Survey of Bisphenol A in Bottled Water Products
http://www.hc-sc.gc.ca/fn-an/securit/packag-emball/bpa/bpa_survey-enquete-bot-bou-eng.php

http://www.bisphenol-a.org/whatsNew/20090709.html

Government of Canada Takes Action on Another Chemical of Concern: Bisphenol A

http://www.hc-sc.gc.ca/ahc-asc/media/nr-cp/_2008/2008_59-eng.php

Bisphenol A

News Release
2008-59
April 18, 2008
For immediate release

OTTAWA – The Honourable Tony Clement, Minister of Health, and the Honourable John Baird, Minister of the Environment, today announced that the Government is taking action to protect the health of Canadians and the environment from another chemical of concern.

Canada is the first country in the world to complete a risk assessment of bisphenol A in consultation with industry and other stakeholders, and to initiate a 60 day public comment period on whether to ban the importation, sale and advertising of polycarbonate baby bottles which contain bisphenol A.

The comment period will begin on April 19, 2008, once the Government publishes a summary notice of its assessment findings in Canada Gazette, Part 1.

“Canada has been the first country in the world to conduct risk assessments on a number of chemicals of concern, as a result of a new initiative announced by the Prime Minister on December 8, 2006 known as the Chemicals Management Plan,” said Minister Clement.“We have immediately taken action on bisphenol A, because we believe it is our responsibility to ensure families, Canadians and our environment are not exposed to a potentially harmful chemical.”

Health Canada’s screening assessment of bisphenol A primarily focused on its impacts on newborns and infants up to 18 months of age; however, health risks for Canadians of all ages were considered in the screening.

It was determined that the main source of exposure for newborns and infants is through the use of polycarbonate baby bottles when they are exposed to high temperatures and the migration of bisphenol A from cans into infant formula. The scientists concluded in this assessment that bisphenol A exposure to newborns and infants is below levels that may pose a risk, however, the gap between exposure and effect is not large enough.

To be prudent, the Government of Canada is proposing to reduce bisphenol A exposure in infants and newborns by proposing a number of actions: to ban polycarbonate baby bottles; to develop stringent migration targets for bisphenol A in infant formula cans; to work with industry to develop alternative food packaging and develop a code of practice; and to list bisphenol A under Schedule 1 of the Canadian Environmental Protection Act.

Environment Canada scientists also found that at low levels, bisphenol A can harm fish and aquatic organisms over time. Studies indicate that it can currently be found in wastewater and sludge treatment plants.

“When it comes to Canada’s environment, you can’t put a price on safety,” said Minister Baird. “Not only are we finding out about the health impacts of bisphenol A, but the environmental impacts as well. That’s why our Government will be moving forward and will work with the provinces and stakeholders to keep bisphenol A out of our environment, and take the necessary measures to ensure its safe use and disposal.”

For more information, please visit the Next link will take you to another Web site Chemical’s Management Web site or call 1-866-891-4542.

http://www.hc-sc.gc.ca/ahc-asc/media/nr-cp/_2008/2008_59-eng.php

Health Canada bisphenol A announcement imminent

http://www.cbc.ca/consumer/story/2008/04/15/bisphenol.html
CBC News

Health Canada is expected to classify bisphenol A as a dangerous substance as early as Wednesday, which could lead to regulations on the increasingly controversial chemical.

The move would make the department the first regulatory body anywhere in the world to rule that bisphenol A (BPA) endangers people and the environment, according to a report in the Globe and Mail.

When contacted by the CBC Tuesday afternoon, Health Canada spokesman Alastair Sinclair would not comment on whether an announcement is imminent.

BPA, which is used to make many hard plastic toys, bottles and food containers, is thought to mimic the hormone estrogen. Recent independent studies link the chemical to breast cancer, obesity, infertility and insulin-resistance in rodents.

Conversely, the plastics industry vigorously defends the chemical, noting it has been used widely for 50 years.

The Health Canada evaluation of bisphenol A was launched last year as part of a study about 200 chemicals the federal government has designated for more careful research.

Once the department, along with Environment Canada, releases its draft assessment of BPA, a 60-day public comment period will follow. Ottawa then has a year in which to issue a report outlining how it will control exposure, assuming that no new information comes out of the public comment period.

But some retailers aren’t waiting for an official announcement.

Canada’s largest sporting-goods retailer said Tuesday it is pulling all water bottles that contain BPA from its more than 500 stores.

Bob Sartor, chief executive officer of Forzani Group, said the company began removing the bottles early Tuesday, after reports Health Canada is about to designate BPA as dangerous. He says Forzani Group stores, which include Sport Check, Athlete’s World and Coast Mountain Sports, will provide refunds for any bottles with receipts.

In December, Vancouver-based Mountain Equipment Co-op became the first major Canadian retailer to pull polycarbonate containers from its store shelves. Lululemon Athletica Inc., also Vancouver-based, announced plans later the same month to stop selling plastic water bottles that contain bisphenol A.

With files from the Canadian Press

Read more: http://www.cbc.ca/consumer/story/2008/04/15/bisphenol.html#ixzz0yJy4NbYi

http://www.cbc.ca/consumer/story/2008/04/15/bisphenol.html

Cash receipts pose risk for BPA exposure: Study

BY BRETT RUSKIN, POSTMEDIA NEWS AUGUST 30, 2010

http://www.vancouversun.com/health/Cash+receipts+pose+risk+exposure+Study/3459858/story.html

A series of recent studies have found high levels of the toxin in an unlikely but ubiquitous place: cash register receipts.

A series of recent studies have found high levels of the toxin in an unlikely but ubiquitous place: cash register receipts.

Photograph by: Photos.com, canada.com

OTTAWA — The next plastic water bottle you buy won’t have bisphenol A in it, but the receipt might. A series of recent studies have found high levels of the toxin in an unlikely but ubiquitous place: cash register receipts.

One study found that touching a receipt for five seconds with a single fingertip wiped off up to 23 micrograms of bisphenol A (BPA). The chemical could then find its way onto food and be ingested. The amount wiped off increases tenfold when all fingers contact the paper and “by an order of magnitude,” scientists say, when the paper is crumpled in one’s palm.

The full article appears in the September issue of Analytical and Bioanalytical Chemistry, a German scientific journal.

BPA has been in the news since 2007 when some retailers pulled hard plastic bottles from their shelves. There was concern that trace amounts of the chemical were seeping into the water. A year later the federal government announced that Canada would be the first country to ban BPA from plastic food containers.

All calculations that deal with BPA levels are intangibly small, measured in micrograms and parts-per-billion. Health Canada says it is dangerous to consume more than 25 micrograms per kilogram of body mass per day. But levels even lower than that may be too much. A 2009 research group found “long-term adverse reproductive and carcinogenic effects” in mice given only one microgram per kilogram of body mass.

There is much discussion on the effect of BPA on humans, but no conclusive testing has been done to support or rebut detrimental claims. One certainty is that there is a lot of BPA in cash receipts.

Receipts, and theatre and concert tickets are all printed on thermal paper. The dye is already part of the paper, which makes for an inexpensive and reliable printing process. When heat is applied, a solvent in the paper melts and allows dye to mix with BPA and darken, which produces the desired text.

Scientists in Boston have analysed the chemicals in thermal paper. In July, researchers from the Warner Babcock Institute took receipts from 10 businesses and extracted all the BPA. They found between 3,000 and 19,000 micrograms in the 30-centimetre strips.

That much BPA is more than 12 times Health Canada’s limit for a 60-kilogram person, although it’s unlikely that the entire amount would wipe off in normal use.

“Ideally, there wouldn’t be any at all,” said Janelle Witzel of Environmental Defence, a group lobbying against harmful chemicals.

“One of our main concerns is potential ingestion,” she said. “After handling a receipt or before a meal, like everything else, just be sure to wash your hands.”

Other suggestions include keeping receipts away from children and toddlers, and separate from unpackaged foods in grocery bags.

It’s difficult to avoid BPA in receipts.

“Anywhere you go now, minus a few mom-and-pop stores, you look at your receipt and it’s thermal paper,” said Jesse Gonzalez, an employee at Wedge Paper Products.

The Mississauga, Ont.-based company distributes cash register paper rolls to businesses across North America. “The quickest way to tell is by taking your fingernail and scratching it. It’ll leave a mark and that’s how you can tell it’s thermal paper.”

Gonzalez said BPA-free thermal paper is more expensive to produce.

However, he said right now about half of his company’s shipments are BPA-free, because customers are requesting it.

Prior to the receipt studies, scientists had focused on BPA exposure from food packaging.

In 2009, Health Canada measured the amount of BPA that seeped into canned soft drinks from the cans’ inner lining. On average, 0.2 micrograms of BPA were ingested with each soft drink — a fraction of the amount wiped off a receipt.

In animal tests, BPA has been linked to ovarian and prostate cancer, obesity and diabetes, among other illnesses. Earlier this month, Statistics Canada released a study estimating that 91 per cent of Canadians had measurable levels of BPA in their urine.

Ottawa Citizen

© Copyright (c) The Ottawa Citizen

Read more:http://www.vancouversun.com/health/Cash+receipts+pose+risk+exposure+Study/3459858/story.html#ixzz0yJybcT6q

http://www.vancouversun.com/health/Cash+receipts+pose+risk+exposure+Study/3459858/story.html

Health Canada makes it official: BPA is health hazard

http://www.canada.com/vancouversun/news/story.html?id=e81a7270-aec9-48cb-aad3-b74df38feec0

Canada on Saturday will become the first country to formally declare bisphenol A hazardous to human health and officially inform the baby-product industry it will no longer be able to use the chemical in baby bottles.

BY CANWEST NEWS SERVICE OCTOBER 16, 2008

OTTAWA – Canada on Saturday will become the first country to formally declare bisphenol A hazardous to human health and officially inform the baby-product industry it will no longer be able to use the chemical in baby bottles.
Canada’s announcement comes six months after Health Minister Tony Clement surprised the chemical industry by announcing the government’s plan to place bisphenol A on its list of toxic substances and ban its use in baby bottles.
In unveiling the “precautionary and prudent” move, Clement proposed a limited ban of the widely used chemical, also found in hard plastic sports bottles and the lining of food cans.
Most Canadians “need not be concerned” about the health effects of bisphenol A, Clement said at the time. “This is not the case for newborns and infants.”
The government’s final decision will appear in the Canada Gazette, which publishes the official regulations of the government.
Rick Smith, executive director of Environmental Defence and co-author of the forthcoming book Slow Death by Rubber Duck: How the Toxic Chemistry of Everyday Life Affects Our Health, said the expected declaration is a “good start.”
But he said new evidence continues to pile up, pointing to the detrimental health effects of bisphenol A on adults.
“There’s new science coming out on a weekly basis pointing to this chemical being a health concern for adults. Baby bottles are a good start, but the government now needs to take a look at getting this chemical out of the lining in cans.”
The latest research, the first large BPA study in humans published last month by the prestigious Journal of the American Medical Association, found a “significant relationship” between exposure to the ubiquitous estrogenic chemical and heart disease, diabetes and liver problems.
Meanwhile, the U.S. Food and Drug Administration is under fire after determining last month in a draft report that BPA was safe for food storage. On Thursday, the Washington Post published an editorial arguing the FDA’s final recommendation, expected this month, could be “seen as less than fully independent.”
The influential newspaper cited the recent donation of $5 million to the University of Michigan’s Risk Science Center from Charles Gelman, the retired head of a medical device manufacturing company and outspoken proponent of bisphenol A.
The acting director of the university centre is Martin Philbert, a toxicologist who is also head of the FDA advisory panel poised to deliver its risk assessment of BPA.
Philbert did not disclose the gift to the agency as part of the disclosure process when he was appointed to the panel; he told the Milwaukee Journal Sentinel he did not need to, since he does not stand to gain from it. The FDA is looking into a possible conflict of interest.

© (c) CanWest MediaWorks Publications Inc.

http://www.canada.com/vancouversun/news/story.html?id=e81a7270-aec9-48cb-aad3-b74df38feec0

NEW STUDY CONCLUDES NO EFFECTS FROM BPA ON NERVOUS SYSTEM

Study Helps Answer Key Research Questions

February 17, 2010

ARLINGTON, VA (Feb. 17,  2010) — The American Chemistry Council (ACC) today commented on a significant study published online in the scientific journal Toxicological Sciences. Quotes below may be attributed to Steven G. Hentges, Ph.D., ACC’s Polycarbonate/BPA Global Group:

“This new study, which exposed pregnant rodents to a range of BPA dietary doses from low to high, concluded that BPA had no effects on brain development or behavior in their offspring that had been exposed to BPA in utero and throughout development.  The robust study was conducted by highly qualified researchers at WIL Research Laboratories.

“This study follows on the heels of a recent low-dose study by EPA that also explored the potential effects of BPA at very early stages of life in rodents and that found even low doses of BPA did not affect the brain, reproduction or development.  Both of these studies – examining potential effects on brain development and behavior at low doses – address the areas of “some concern” which the National Toxicology Program had previously identified as appropriate for additional research.

“Regulatory agencies from around the world have concluded that the science supports the safety of BPA for people of all ages in its current uses.  Plastics made with BPA contribute to the safety and convenience of everyday life because of their durability, clarity and shatter-resistance.  Can liners made with BPA are essential components to help to protect the safety of packaged foods and preserve products from spoilage and contamination.”

Background on the study
The study is titled “Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats,” (Donald G. Stump, et al.).  In the study, pregnant female rats were exposed to BPA via direct consumption of the diet at dosage levels that spanned the range from low doses, as used in some published studies reporting developmental neurotoxicity, to a high dose that was anticipated to result in systemic toxicity in the pregnant rat (0, 0.01, 0.1, 5, 50, and 150 mg/kg/day).  The offspring, exposed to BPA in utero, via milk while nursing and via direct consumption through the diet once they started to feed, were studied for functional or morphological effects on their nervous systems.  The study concluded that there were no neurologic or neurobehavioral effects related to BPA at any dose tested.

Bisphenol A from Wikipedia

Bisphenol A, commonly abbreviated as BPA, is an organic compound with two phenol functional groups used to make polycarbonate plastic and epoxy resins, along with other applications.
Known to be estrogenic since the mid 1930s, concerns about the use of bisphenol A in consumer products were regularly reported in the news media in 2008 after several governments issued reports questioning its safety, thus prompting some retailers to remove products containing it from their shelves. A 2010 report from the United States Food and Drug Administration (FDA) raised further concerns regarding exposure of fetuses, infants, and young children.

Bisphenol A Chart 1Bisphenol A Chart 1a

Synthesis

Bisphenol A was first reported by A.P. Dianin in 1891.
It is prepared by the condensation of acetone (hence the suffix A in the name) with two equivalents of phenol. The reaction is catalyzed by an acid, such as hydrochloric acid (HCl) or a sulfonated polystyrene resin. Typically, a large excess of phenol is used to ensure full condensation:
(CH3)2CO + 2 C6H5OH → (CH3)2C(C6H4OH)2 + H2O
A large number of ketones undergo analogous condensation reactions. Commercial production of BPA requires distillation – either extraction of BPA from many resinous byproducts under high vacuum, or solvent-based extraction using additional phenol followed by distillation.

Use

Further information: Polycarbonate

Bisphenol -A 2d chart

Bisphenol A is used primarily to make plastics, and products containing bisphenol A-based plastics have been in commerce for more than 50 years. It is a key monomer in production of epoxy resins and in the most common form of polycarbonate plastic. Polycarbonate plastic, which is clear and nearly shatter-proof, is used to make a variety of common products including baby and water bottles, sports equipment, medical and dental devices, dental fillings and sealants, eyeglass lenses, CDs and DVDs, and household electronics. BPA is also used in the synthesis of polysulfones and polyether ketones, as an antioxidant in some plasticizers, and as a polymerization inhibitor in PVC. Epoxy resins containing bisphenol A are used as coatings on the inside of almost all food and beverage cans, however, due to BPA health concerns, in Japan epoxy coating was mostly replaced by PET film. Bisphenol A is also a precursor to the flame retardant tetrabromobisphenol A, and was formerly used as a fungicide. Bisphenol A is a preferred color developer in carbonless copy paper and thermal paper, with the most common public exposure coming from some thermal point of sale receipt paper. BPA-based products are also used in foundry castings and for lining water pipes.
Global production of bisphenol A was estimated to be over 2 million tonnes in 2003, and more than 2.2 Mt in 2009. In the U.S., it is manufactured by Bayer MaterialScience, Dow Chemical Company, SABIC Innovative Plastics (formerly GE Plastics), Hexion Specialty Chemicals, and Sunoco Chemicals. In 2004, these companies produced just over 1 million t of bisphenol A, up from just 7,260 t in 1991. In 2003, annual U.S. consumption was 856,000 t, 72% of which was used to make polycarbonate plastic and 21% going into epoxy resins. In the US less than 5% of the BPA produced is used in food contact applications.

Identification in plastics
Main article: Resin identification code

07

03

There are seven classes of plastics used in packaging applications. Type 7 is the catch-all “other” class, and some type 7 plastics, such as polycarbonate (sometimes identified with the letters “PC” near the recycling symbol) and epoxy resins, are made from bisphenol A monomer.
Type 3 (PVC) can also contain bisphenol A as an antioxidant in plasticizers. This is particularly true for “flexible PVC”, but not true for PVC pipes.
Type 6 (polystyrene) neither contains, nor does it break down into bisphenol A, according to the Styrene Information and Research Center, a not for profit organization whose membership represents approximately 95% of the North American styrene industry.

Health effects

Bisphenol A is an endocrine disruptor, which can mimic the body’s own hormones and may lead to negative health effects. Early development appears to be the period of greatest sensitivity to its effects. Regulatory bodies have determined safety levels for humans, but those safety levels are currently being questioned or under review as a result of new scientific studies.
In 2009 the The Endocrine Society released a scientific statement expressing concern over current human exposure to BPA.

Previous studies

In 2007, a consensus statement by 38 experts on bisphenol A concluded that average levels in people are above those that cause harm to many animals in laboratory experiments. A panel convened by the U.S. National Institutes of Health determined that there was “some concern” about BPA’s effects on fetal and infant brain development and behavior. A 2008 report by the U.S. National Toxicology Program (NTP) later agreed with the panel, expressing “some concern for effects on the brain, behavior, and prostate gland in fetuses, infants, and children at current human exposures to bisphenol A,” and “minimal concern for effects on the mammary gland and an earlier age for puberty for females in fetuses, infants, and children at current human exposures to bisphenol A.” The NTP had “negligible concern that exposure of pregnant women to bisphenol A will result in fetal or neonatal mortality, birth defects, or reduced birth weight and growth in their offspring.”

Obesity

A 2008 review has concluded that obesity may be increased as a function of BPA exposure, which “merits concern among scientists and public health officials”. A 2009 review of available studies has concluded that “perinatal BPA exposure acts to exert persistent effects on body weight and adiposity”. Another 2009 review has concluded that “Eliminating exposures to (BPA) and improving nutrition during development offer the potential for reducing obesity and associated diseases”. Other reviews have come with similar conclusions.

Neurological issues
A panel convened by the U.S. National Institutes of Health determined that there was “some concern” about BPA’s effects on fetal and infant brain development and behavior. A 2008 report by the U.S. National Toxicology Program (NTP) later agreed with the panel, expressing “some concern for effects on the brain”. In January 2010 the FDA expressed the same level of concern.
A 2007 review has concluded that BPA, like other xenoestrogens, should be considered as a player within the nervous system that can regulate or alter its functions through multiple pathways. A 2007 review has concluded that low doses of BPA during development have persistent effects on brain structure, function and behavior in rats and mice. A 2008 review concluded that low-dose BPA maternal exposure causes long-term consequences at the level of neurobehavioral development in mice. A 2008 review has concluded that neonatal exposure to Bisphenol-A (BPA) can affect sexually dimorphic brain morphology and neuronal adult phenotypes in mice. A 2008 review has concluded that BPA altered long-term potentiation in the hippocampus and even nanomolar dosage could induce significant effects on memory processes. A 2009 review raised concerns about BPA effect on anteroventral periventricular nucleus.
A 2008 study by the Yale School of Medicine demonstrated that adverse neurological effects occur in non-human primates regularly exposed to bisphenol A at levels equal to the United States Environmental Protection Agency’s (EPA) maximum safe dose of 50 µg/kg/day. This research found a connection between BPA and interference with brain cell connections vital to memory, learning and mood.
Highly controversial claims have been made that BPA could be involved in attention-deficit hyperactivity disorder (ADHD)
A 2010 study with rats prenatally exposed to 40 microg/kg bw BPA has concluded that corticosterone and its actions in the brain are sensitive to the programming effects of BPA.

Disruption of the dopaminergic system

A 2005 review concluded that prenatal and neonatal exposure to BPA in mice can potentiate the central dopaminergic systems, resulting in the supersensitivity to the drugs-of-abuse-induced reward effects and hyperlocomotion.
A 2008 review has concluded that BPA mimics estrogenic activity and impacts various dopaminergic processes to enhance mesolimbic dopamine activity resulting in hyperactivity, attention deficits, and a heightened sensitivity to drugs of abuse.
A 2009 study on rats has concluded that prenatal and neonatal exposure to low-dose BPA causes deficits in development at dorsolateral striatum via altering the function of dopaminergic receptors. Another 2009 study has found associated changes in the dopaminergic system.

Thyroid function

A 2007 review has concluded that bisphenol-A has been shown to bind to thyroid hormone receptor and perhaps have selective effects on its functions.
A 2009 review about environmental chemicals and thyroid function, raised concerns about BPA effects on triiodothyronine and concluded that “available evidence suggests that governing agencies need to regulate the use of thyroid-disrupting chemicals, particularly as such uses relate exposures of pregnant women, neonates and small children to the agents”.
A 2009 review summarized BPA adverse effects on thyroid hormone action.

Cancer research

According to the WHO’s INFOSAN, “animal studies have not provided convincing evidence of risk of cancer from BPA exposure.”
Neither the U.S. Environmental Protection Agency nor the International Agency for Research on Cancer has evaluated bisphenol A for possible carcinogenic activity.
A 2010 review concluded that Bisphenol A may increase cancer risk.

Breast cancer

Further information: Risk factors of breast cancer#Bisphenol A
A 2008 review has concluded that “perinatal exposure to (…) low doses of (..) BPA, alters breast development and increases breast cancer risk”.
Another 2008 review concluded that ” animal experiments and epidemiological data strengthen the hypothesis that foetal exposure to xenoestrogens may be an underlying cause of the increased incidence of breast cancer observed over the last 50 years”.
A 2009 in vitro study has concluded that BPA is able to induce neoplastic transformation in human breast epithelial cells. Another 2009 study concluded that maternal oral exposure to low concentrations of BPA during lactation increases mammary carcinogenesis in a rodent model.
A 2010 study with the mammary glands of the offspring of pregnant rats treated orally with 0, 25 or 250 µg BPA/kg body weight has found that key proteins involved in signaling pathways such as cellular proliferation were regulated at the protein level by BPA.
A 2010 study has found that BPA may reduce sensitivity to chemotherapy treatment of specific tumors.

Neuroblastoma

In vitro studies have suggested that BPA can promote the growth of neuroblastoma cells. A 2010 in vitro study has concluded that BPA potently promote invasion and metastasis of neuroblastoma cells through overexpression of MMP-2 and MMP-9 as well as downregulation of TIMP2.

Prostate development and cancer

A 1997 study in mice has found that neonatal BPA exposure of 2 μg/kg increased adult prostate weight. A 2005 study in mice has found that neonatal BPA exposure at 10 μg/kg disrupted the development of the fetal mouse prostate. A 2006 study in rats has shown that neonatal bisphenol A exposure at 10 μg/kg levels increases prostate gland susceptibility to adult-onset precancerous lesions and hormonal carcinogenesis. A 2007 in vitro study has found that BPA within the range of concentrations currently measured in human serum is associated with permanently increase in prostate size. A 2009 study has found that newborn rats exposed to a low-dose of BPA (10 µg/kg) increased prostate cancer susceptibility when adults.

DNA methylation

Bisphenol A suppress DNA methylation (by increased hypomethylation) which is linked to epigenetic changes.

Reproductive system and sexual behavior research
A series of studies made in 2009 found:
Mouse ovary anomalies from exposure as low as 1 µg/kg, concluded that BPA exposure causes long-term adverse reproductive and carcinogenic effects if exposure occurs during prenatal critical periods of differentiation.
Neonatal exposure of as low as 50 µg/kg disrupts ovarian development in mice.
Neonatal BPA exposition of as low as 50 µg/kg permanently alters the hypothalamic estrogen-dependent mechanisms that govern sexual behavior in the adult female rat.
Prenatal exposure to BPA at levels of (10 μg/kg/day) affects behavioral sexual differentiation in male monkeys.
In placental JEG3 cells in vitro BPA may reduce estrogen synthesis.
BPA exposure disrupted the blood-testis barrier when administered to immature, but not to adult, rats.
Exposure to BPA in the workplace was associated with self-reported adult male sexual dysfunction.
A rodent study, funded by EPA and conducted by some of its scientists, concluded that, compared with ethinyl estradiol, low-dose exposures of bisphenol A (BPA) showed no effects on several reproductive functions and behavioral activities measured in female rats. That study was criticized as flawed for using polycabornate cages in the experiment and the claimed resistance of the rats to estradiol but that claim was contested by the authors and others.
A 2010 study with mice concluded that BPA exposure in utero leads to permanent DNA alterations in sensitivity to estrogen.

General research

At an Endocrine Society meeting in 2009, new research reported data from animals experimentally treated with BPA. Studies presented at the group’s annual meeting show BPA can affect the hearts of women, can permanently damage the DNA of mice, and appear to be entering the human body from a variety of unknown sources.
A 2009 in vitro study on cytotrophoblasts cells has found cytoxic effects in exposure of BPA doses from 0.0002 to 0.2 micrograms per millilitre and concluded this finding “suggests that exposure of placental cells to low doses of BPA may cause detrimental effects, leading in vivo to adverse pregnancy outcomes such as preeclampsia, intrauterine growth restriction, prematurity and pregnancy loss”
A 2009 study in rats concluded that BPA, at the reference safe limit for human exposure, was found to impact intestinal permeability and may represent a risk factor in female offspring for developing severe colonic inflammation in adulthood.
A 2010 study on mice has concluded that perinatal exposure to 10 micrograms/mL of BPA in drinking water enhances allergic sensitization and bronchial inflammation and responsiveness in an animal model of asthma.

Studies on humans

Lang study and heart disease
The first large study of health effects on humans associated with bisphenol A exposure was published in September 2008 by Iain Lang and colleagues in the Journal of the American Medical Association.[19][94] The cross-sectional study of almost 1,500 people assessed exposure to bisphenol A by looking at levels of the chemical in urine. The authors found that higher bisphenol A levels were significantly associated with heart disease, diabetes, and abnormally high levels of certain liver enzymes. An editorial in the same issue notes that while this preliminary study needs to be confirmed and cannot prove causality, there is precedent for analogous effects in animal studies, which “add[s] biological plausibility to the results reported by Lang et al.”
A later similar study performed by the same group of scientists, published in January 2010, confirmed, despite of lower concentrations of BPA in the second study sample, an associated increased risk for heart disease but not for diabetes or liver enzymes.

Other studies

Studies have associated recurrent miscarriage with BPA serum concentrations, oxidative stress and inflamattion in postmenopausal women with urinary concentrations, externalizing behaviors in two-year old children, especially among female children, with mother’s urinary concentrations, altered hormone levels in men and declining male sexual function with urinary concentrations.

Historical studies

The first evidence of the estrogenicity of bisphenol A came from experiments on rats conducted in the 1930s, but it was not until 1997 that adverse effects of low-dose exposure on laboratory animals were first reported.

Low dose exposure in animals
Low dose exposure in animals

The current U.S. human exposure limit set by the EPA is 50 µg/kg/day.

Xenoestrogen

There is evidence that bisphenol A functions as a xenoestrogen by binding strongly to estrogen-related receptor γ (ERR-γ). This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER). BPA binding to ERR-γ preserves its basal constitutive activity. It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.
Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta, explaining reports of high bisphenol A accumulation in this tissue.

Human exposure sources

“    The problem is, BPA is also a synthetic estrogen, and plastics with BPA can break down, especially when they’re washed, heated or stressed, allowing the chemical to leach into food and water and then enter the human body. That happens to nearly all of us; the CDC has found BPA in the urine of 93% of surveyed Americans over the age of 6. If you don’t have BPA in your body, you’re not living in the modern world.    ”
—The Perils of Plastic, http://www.time.com/time/specials/packages/article/0,28804,1976909_1976908_1976938-2,00.html

TIME Magazine

Bisphenol A has been known to be leached from the plastic lining of canned foods and, to a lesser degree,[citation needed] polycarbonate plastics, especially those that are cleaned with harsh detergents or used to contain acidic or high-temperature liquids. A recent Health Canada study found that the majority of canned soft drinks it tested had low, but measurable levels of bisphenol A. This exposure through metal cans is due to the fact that BPA is an ingredient in the internal coating of food and beverage metal cans used to protect the food from direct contact with metal. While most human exposure is through diet, exposure can also occur through air and through skin absorption.
Free BPA is found in high concentration in thermal paper and carbonless copy paper, which would be expected to be more available for exposure than BPA bound into resin or plastic. Popular uses of thermal paper include airline tickets, event and cinema tickets, labels, and point of sale applications (receipts). While there is little concern for dermal absorption of BPA, free BPA can readily be transferred to skin and residues on hands can be ingested.
Studies by the CDC found bisphenol A in the urine of 95% of adults sampled in 1988–1994 and in 93% of children and adults tested in 2003–04. Infants fed with liquid formula are among the most exposed, and those fed formula from polycarbonate bottles can consume up to 13 micrograms of bisphenol A per kg of body weight per day (μg/kg/day; see table below). The most sensitive animal studies show effects at much lower doses, while the EPA considers exposures up to 50 µg/kg/day to be safe. In 2009, a study found that drinking from polycarbonate bottles increased urinary bisphenol A levels by two thirds, from 1.2 micrograms/gram creatinine to 2 micrograms/gram creatinine.
11 of 13 thermal printing papers contained 8 – 17 g/kg Bisphenol A (BPA). Upon dry finger contact with a thermal paper receipt, roughly 1 μg BPA (0.2 – 6 μg) was transferred to the forefinger and the middle finger. For wet or greasy fingers approximately 10 times were more transferred. Extraction of BPA from the fingers were possible up to 2 hours after exposure.
Consumer groups recommend that people wishing to lower their exposure to bisphenol A avoid canned food and polycarbonate plastic containers (which shares resin identification code 7 with many other plastics) unless the packaging indicates the plastic is bisphenol A-free. The National Toxicology Panel recommends avoiding microwaving food in plastic containers, putting plastics in the dishwasher, or using harsh detergents, to avoid leaching.
A 2009 small US study funded by the EWG has detected an average of 2.8 ng/mL BPA in the blood of 9 out of the 10 umbilical cords tested.
In the US and Canada, BPA has been found in infant liquid formula in concentrations varying from 0.48 to 11 ng/g.[133][134] BPA has been rarely found in infant powder formula (only 1 of 14).
In the US consumption of soda, school lunches, and meals prepared outside the home was statistically significantly associated with higher urinary BPA.
A 2010 study of Austrian, Swiss and German population has suggested polycarbonate (PC) baby bottles as the most prominent role of exposure for infants, and canned food for adults and teenagers.

Estimated daily bisphenol A intake μg-kg-day

Pharmacokinetics

There’s no agreement between scientists of a physiologically-based pharmacokinetic (PBPK) BPA model for humans. The effects of BPA on an organism depends on how much free BPA is available and for how long cells are exposed to it. Glucuronidation in the liver, by conjugation with glucuronic acid to form the metabolite BPA-glucuronide (BPAG), reduces the amount of free BPA, however BPAG can be deconjugated by beta-glucuronidase, an enzyme present in high concentration in placenta and other tissues. Free BPA can also be inactivated by sulfation, a process that can also be reverted by arylsulfatase C.
The best test methods for studying BPA effects are currently under discussion with scientists sharing different opinions.
A 2010 review of 80+ biomonitoring studies concluded that the general population is internally exposed to significant amounts of unconjugated BPA (in the ng/ml blood range). Using GC/MS on 20 samples, BPA was detected in 100% of urine samples with a median of 1.25 ng.ml, and 10% of blood samples (LOD 0.5 ng/ml).
A 2009 research has found that some drugs, like naproxen, salicylic acid, carbamazepine and mefenamic acid can, in vitro, significantly inhibit BPA glucuronidation.
A 2010 study on rats embryos has found that genistein may enhance developmental toxicity of BPA.

Environmental risk

In general, studies have shown that BPA can affect growth, reproduction and development in aquatic organisms. Among freshwater organisms, fish appear to be the most sensitive species. Evidence of endocrine-related effects in fish, aquatic invertebrates, amphibians and reptiles has been reported at environmentally relevant exposure levels lower than those required for acute toxicity. There is a widespread variation in reported values for endocrine-related effects, but many fall in the range of 1μg/L to 1 mg/L.
BPA can contaminate the environment either directly or through degradation of products containing BPA, such as ocean-borne plastic trash.
As an environmental contaminant this compound interferes with nitrogen fixation at the roots of leguminous plants associated with the bacterial symbiont Sinorhizobium meliloti. Despite a half-life in the soil of only 1–10 days, its ubiquity makes it an important pollutant. According to Environment Canada, “initial assessment shows that at low levels, bisphenol A can harm fish and organisms over time. Studies also indicate that it can currently be found in municipal wastewater.”
A 2009 review of the biological impacts of plasticizers on wildlife published by the Royal Society with a focus on annelids (both aquatic and terrestrial), molluscs, crustaceans, insects, fish and amphibians concluded that BPA have been shown to affect reproduction in all studied animal groups, to impair development in crustaceans and amphibians and to induce genetic aberrations.
A large 2010 study of two rivers in Canada found that areas contaminated with hormone-like chemicals including bisphenol A showed females made up 85 per cent of the population of a certain fish, while females made up only 55 per cent in uncontaminated areas.

Government and industry response

World Health Organization

Arguing uncertainty of possible adverse health effects of low dose BPA exposure, especially on the nervous system and on behaviour, and also the differences of exposure of very young children, the WHO announced in November 2009 that it would organize an expert consultation in 2010 to assess BPA safety.

Australia and New Zealand

The Australia and New Zealand Food Safety Authority (Food Standards Australia New Zealand) does not see any health risk with bisphenol A baby bottles if the manufacturer’s instructions are followed. Levels of exposure are very low and do not pose a significant health risk. It added that “the move by overseas manufacturers to stop using BPA in baby bottles is a voluntary action and not the result of a specific action by regulators.” It suggests the use of glass baby bottles if parents have any concerns.

Canada

In April 2008, Health Canada concluded that, while adverse health effects were not expected, the margin of safety was too small for formula-fed infants and proposed classifying the chemical as “‘toxic’ to human health and the environment.”
After the release of that assessment, Canadian Health Minister Tony Clement announced Canada’s intent to ban the import, sale, and advertisement of polycarbonate baby bottles containing bisphenol A due to safety concerns, and investigate ways to reduce BPA contamination of baby formula packaged in metal cans. While the agency concluded that human exposures were less than levels believed to be unsafe, the margin of safety was not high enough for formula-fed infants. Around the same time, Wal-Mart announced that it was immediately ceasing sales in all its Canadian stores of food containers, water and baby bottles, sippy cups, and pacifiers containing bisphenol A, and that it would phase out baby bottles made with it in U.S. stores by early 2009. Nalgene also announced it will stop using the chemical in its products, and Toys-R-Us said it too will cease selling baby bottles made from it. Subsequent news reports showed many retailers removing polycarbonate drinking products from their shelves.

The federal government has formally declared bisphenol A a hazardous substance as of October 2008 and is now placed on its list of toxic substances. Health officials wrote in Canada Gazette that “It is concluded that bisphenol A be considered as a substance that may be entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health.”The federal ministries of health and the environment announced they would seek to restrict imports, sales and advertising of polycarbonate baby bottles containing BPA.
In its statement Gc.ca released on 18 October 2008, Health Canada noted that “bisphenol A exposure to newborns and infants is below levels that cause effects” and that the “general public need not be concerned”.
On Aug. 25, 2010, Environment Canada confirmed they are in the process of adding bisphenol-A to its list of toxic substances.[ref]http://www.thestar.com/article/852096–in-historic-move-canada-to-list-bpa-as-toxic

Europe

European Union

The updated 2008 European Union Risk Assessment Report on bisphenol A, published in June 2008 by the European Commission and European Food Safety Authority (EFSA) concluded that bisphenol A-based products, such as polycarbonate plastic and epoxy resins, are safe for consumers and the environment when used as intended.[159] By October 2008, after the Lang Study was published, the EFSA issued a statement concluding that the study provided no grounds to revise the current TDI (Tolerable Daily Intake) level for BPA of 0.05 mg/kg bodyweight.
A 2009 scientific study criticized the European risk assessment processes of endocrine disruptors, including BPA.
On 22 December 2009 the EU Environment ministers released a statement expressing concerns over recent studies showing adverse effects of exposure to endocrine disrupters.
The EFSA is scheduled to release another opinion on BPA by May 2010.

Denmark

In May 2009, the Danish parliament passed a resolution to ban the use of BPA in baby bottles, which has not been enacted by April 2010. In March 2010 a temporary ban was declared by the Health Minister

Belgium

On March 2010, senator Philippe Mahoux proposed legislation to ban BPA in food contact plastics.

France

On 5 February 2010, the French Food Safety Agency (AFSSA) questioned the previous assessments of the health risks of BPA, especially in regard to behavioral effects observed in rat pups following exposure in utero and during the first months of life. On April 2010 the AFFSA suggested the adoption of better labels for food products containing BPA.

On 24 March 2010 French Senate unanimously approved a proposition of law to ban BPA from baby bottles, the proposition still depends of Assembly approval.

Germany

On 19 September 2008, the German Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung, BfR) stated that there was no reason to change the current risk assessment for bisphenol A on the basis of the Lang Study.
In October, 2009, the German environmental organization Bund für Umwelt und Naturschutz Deutschland requested a ban on BPA for children’s products, especially pacifiers,[171] and products that make contact with food. In response, some manufacturers voluntarily removed the problematic pacifiers from the market.

Netherlands

On 6 November 2008, the Dutch Food and Consumer Product Safety Authority (VWA), stated in a newsletter that baby bottles made from polycarbonate plastic do not release measurable concentrations of bisphenol A and therefore are safe to use.

Switzerland

In February 2009 the Swiss Federal Office for Public Health, based on reports of other health agencies, stated that the intake of bisphenol A from food represents no risk to the consumer, including newborns and infants. However, in the same statement it advised for proper use of polycarbonate baby bottles and listed alternativesSweden
By May 2010 the Swedish Chemicals Agency asked for a BPA ban in baby bottles but the Swedish Food Safety Authority prefers to await the expected European Food Safety Authority’s updated review. The Minister of Environment said to wait for the EFSA review but not for too long.

UK

In December 2009 responding to a letter from a group of seven scientists that urged the UK Government to ‘adopt a standpoint consistent with the approach taken by other Governments who have ended the use of BPA in food contact products marketed at children’ the UK Food Standards Agency reaffirmed in January 2009 their view that ‘exposure of UK consumers to BPA from all sources, including food contact materials, was well below levels considered harmful

Japan

Between 1998 and 2003, the canning industry voluntarily replaced their BPA-containing epoxy resin can liners with BPA-free polyethylene terephthalate (PET) in many of their products. For other products, they switched to a different epoxy lining that yielded much less migration of BPA into food than the previously used resin. In addition, polycarbonate tableware for school lunches was replaced by BPA-free plastics. As a result of these changes, Japanese risk assessors have found that virtually no BPA is detectable in canned foods or drinks, and blood levels of BPA in people have declined dramatically (50% in one study).

United States

September 2008
In September, the National Toxicology Program finalized their report on bisphenol A, finding “some concern”, mid-point of a five-level scale, that infants were at risk from exposure to the chemical.[32]
At that time, the FDA reassured consumers that current limits were safe, but convened an outside panel of experts to review the issue. The Lang study was also released that month, and David Melzer, a co-author of the study, presented the results of the study before the FDA panel.
The editorial accompanying the Lang study’s publication in JAMA criticized the FDA’s assessment of bisphenol A: “A fundamental problem is that the current ADI [acceptable daily intake] for BPA is based on experiments conducted in the early 1980s using outdated methods (only very high doses were tested) and insensitive assays. More recent findings from independent scientists were rejected by the FDA, apparently because those investigators did not follow the outdated testing guidelines for environmental chemicals, whereas studies using the outdated, insensitive assays (predominantly involving studies funded by the chemical industry) are given more weight in arriving at the conclusion that BPA is not harmful at current exposure levels.”

March 2009
Sunoco, a producer of gasoline and chemicals, is now refusing to sell the chemical to companies for use in food and water containers for children younger than 3, saying it can’t be certain of the compound’s safety. Sunoco plans to require its customers to guarantee that the chemical will not be used in children’s food products.
The six largest US companies which commercialize baby bottles decided to stop using bisphenol A in their products. Suffolk County, New York banned baby beverage containers made with bisphenol A.
On March 13 leaders from the House and Senate proposed legislation to ban bisphenol A.
In the same month, Rochelle Tyl, author of two studies used by FDA to assert BPA safety in August 2008, said those studies didn’t claim that BPA is safe since they weren’t designed to cover all aspects of the chemical’s effects.

May 2009
The first US jurisdictions to pass regulations limiting or banning BPA were Minnesota and Chicago. Minnesota’s regulation takes effect in 2010, “manufacturers of … children’s products containing BPA may not sell them in the state after Jan. 1, 2010. The ban extends to all retailers in the state a year later.” The products impacted are known as sippy cups and baby bottles. The City of Chicago adopted a similar ban shortly thereafter. Coverage of Chicago’s ban in the news showed a relentless opposition by the industry. A Chicago Tribune article noted an up-hill battle while passing legislation, “[industry officials] used FDA’s position on the issue when they tried to block the city’s measure.”
In May 2009 the Washington Post accused the manufacturers of food and beverage containers and some of their biggest customers of trying to devise a public relations and lobbying strategy to block government BPA bans.

June 2009
In June 2009, the FDA announced the decision to reconsider the BPA safety levels.
Connecticut was the first US state to ban bisphenol A from infant formula and baby food containers, as well from any reusable food or beverage container.

July 2009
The California Environmental Protection Agency’s Developmental and Reproductive Toxicant Identification Committee unanimously voted against placing Bisphenol A on the state’s list of chemicals that are believed to cause reproductive harm. The panel, although concerned over the growing scientific research showing BPA’s reproductive harm in animals, found that there was insufficient data of the effects in humans. Critics point out that the same panel failed to add second-hand smoke to the list until 2006, and only one chemical was added to the list in the last three years.

August 2009
On August 3, Massachusetts’ Department of Public Health advised mothers to take certain actions to prevent possible health impact in children. Mothers with children up to two years old were advised to limit exposure by avoiding products that might contain BPA, such as plastic drinking bottles and other plastic materials with recycling codes of 7 or 3.
The Milwaukee Journal Sentinel, as part of an ongoing investigative series into BPA and its effects, revealed plans by the Society of the Plastics Industry to execute a major public relations blitz to promote BPA, including plans to attack and discredit those who report or comment negatively on the monomer and its effects.

September 2009
On September 29, the U.S. Environmental Protection Agency announced that it is evaluating BPA, and another five chemicals, for action plan development.

October 2009
On October 28, the NIH announced $30,000,000 in stimulus grants to study the health effects of BPA. This money is expected to result in many peer-reviewed publications.

November 2009
The Consumer Reports magazine published an analysis of BPA content in some canned foods and beverages, where in specific cases the content of a single can of food could exceed the current FDA Cumulative Exposure Daily Intake.

January 2010
On January 15 the FDA expressed “some concern”, the middle level in the scale of concerns, about the potential effects of BPA on the brain, behavior, and prostate gland in fetuses, infants, and young children and announced it was taking reasonable steps to reduce human exposure to BPA in the food supply. However, the FDA is not recommending that families change the use of infant formula or foods, as it sees the benefit of a stable source of good nutrition as outweighing the potential risk from BPA exposure.
On the same date the U.S. Department of Health & Human Services released information to help parents to reduce children’s BPA exposure.

February 2010
According to The Milwaukee Journal Sentinel, which supports a BPA ban, after lobbyists for the chemical industry met with administration officials, the EPA delayed BPA regulation and did not include the chemical in an action plan released December 30, 2009.
Many US states are considering some sort of BPA ban.

March 2010
On March 29, the EPA declared BPA a “chemical of concern”.

April 2010
The 2008–2009 Annual Report of the President’s Cancer Panel declared: “because of the long latency period of many cancers, the available evidence argues for a precautionary approach to these diverse chemicals, which include (…) bisphenol A”

Meanwhile, as of April, General Mills has announced that they have found a BPA-free alternative can liner that apparently works even with tomatoes, a highly acidic product that has long baffled the industry in terms of finding a suitable substitute. They say with the next tomato harvest, they will begin using it in tomato products sold by their organic foods subsidiary, Muir Glen. Thus far, there has been no word on whether General Mills will use BPA-free alternatives on any of its other canned products.

Lead Mercury and Bisphenol-A  Levels in the blood of Canadian People

http://www.statcan.gc.ca/daily-quotidien/100816/dq100816a-eng.htm

2007 to 2009

New data from the Canadian Health Measures Survey (CHMS) show that blood lead concentrations in the Canadian population have fallen dramatically since they were last measured 30 years ago. Furthermore, 91% of Canadians aged 6 to 79 had detectable concentrations of bisphenol A (BPA) in their urine and 88% had detectable concentrations of total mercury in their blood. The CHMS analyzed blood and urine samples for indicators of more than 80 environmental contaminants and chemical substances, most of which were measured for the first time in a representative sample of Canadians.

Lead

Blood lead concentrations were measured at the national level for the first time in 30 years by the CHMS from 2007 to 2009. Less than 1% of Canadians aged 6 to 79 had concentrations of lead at or above the intervention level of 10 micrograms per decilitre of blood.

The geometric mean concentration of blood lead for Canadians aged 6 to 79 was 1.34 micrograms per decilitre.

Blood lead concentrations were higher in adults than in children. Older adults (aged 60 to 79) had the highest concentrations. Children aged 6 to 11 and teens aged 12 to 19 had the lowest.

Controlling for age group and sex, higher concentrations of lead in the blood were associated with lower household income, being born outside Canada, living in a dwelling that was at least 50 years old, current or former smoking, and drinking alcohol at least once a week.

Although lead was detected in 100% of the population, concentrations have fallen dramatically over the past 30 years. The geometric mean lead concentration for people aged 6 to 79 measured by the CHMS between 2007 and 2009 was about one-third of the concentration measured in the 1978/1979 Canada Health Survey for the same age group.

In 1978/1979, about 27% of Canadians aged 6 to 79 had blood lead concentrations at or above the intervention level, compared with less than 1% from 2007 to 2009.

Note to readers

This third release of data from the Canadian Health Measures Survey (CHMS) includes information on more than 80 environmental contaminants and chemical substances that were measured in the Canadian population from 2007 to 2009. These baseline data on the presence of environmental chemicals in the population will help track trends as data from subsequent cycles of the CHMS become available.

This release provides information on laboratory measures related to the environment, such as heavy metals (lead, mercury and cadmium), pesticides, herbicides, PCBs and perfluorinated compounds. These indicators were collected from March 2007 to February 2009 from a representative sample of about 5,600 Canadians aged 6 to 79 years at 15 sites across the country.

Lead is a heavy metal that occurs naturally in the environment. People can be exposed to lead from air, water, food, dust, consumer products and certain occupations and hobbies. High lead levels can increase the risk of nervous system and kidney damage.

Bisphenol A (BPA) is an industrial chemical used primarily in the production of polycarbonate plastic and epoxy resins for food containers, water bottles and protective linings for canned food and beverages. It does not occur naturally in the environment. Some studies on animals suggest that low levels of exposure to BPA very early in life can affect neural development and behaviour; however, there is some uncertainty in interpreting how these findings might be relevant to human health.

Mercury is found throughout the environment. The general population is exposed primarily through consuming fish and seafood. Chronic exposure to elevated levels may cause a number of health effects, including numbness and tingling in the extremities, blurred vision, deafness and intellectual impairment. Prenatal exposure may cause neurological and developmental delays.

Micrograms per litre and micrograms per decilitre are measures of concentration that reflect the number of molecules per litre or decilitre of blood or urine.

A geometric mean is a type of average that is less influenced by extreme values than the traditional arithmetic mean. The geometric mean provides a better estimate of central tendency for highly skewed data. This type of data is common in the measurement of environmental chemicals in blood and urine.

This decline reflects the removal of major sources of lead from the environment. Since the 1970s, lead has no longer been added to automotive gasoline or used as solder in food cans, and lead limits in paint have been reduced.

Bisphenol A (BPA)

Bisphenol A (BPA) concentrations were measured for the first time at a national level in Canada by the CHMS from 2007 to 2009.

Canadians aged 6 to 79 had a geometric mean concentration of urinary BPA of 1.16 micrograms per litre. This is consistent with results from international studies reporting mean or median concentrations of 1 to 3 micrograms per litre.

Concentrations of BPA in urine based on volume were higher for children aged 6 to 11 than they were for adults aged 40 to 79. Moreover, the highest concentrations were measured in teens aged 12 to 19.

Mercury

The CHMS measured total mercury in blood samples provided by participants aged 6 to 79. From 2007 to 2009, total blood mercury was detected in 88% of Canadians in this age group.

The geometric mean concentration across this population was 0.69 micrograms per litre. Mercury concentrations were lower for children and teens aged 6 to 19 than for adults aged 20 to 79.

Definitions, data sources and methods: survey number 5071.

The article “Lead and bisphenol A concentrations in the Canadian population,” which is part of today’s Health Reports, Vol. 21, no. 3 (82-003-X, free), online release, is now available. From the Key resource module of our website, choose Publications.

Fact sheets on lead, bisphenol A and mercury are also available in Health Fact Sheets(82-625-X, free).

The publication Canadian Health Measures Survey: Cycle 1 Data Tables, 2007 to 2009, no. 2 (82-623-X, free), is now available from the Key resource module of our website under Publications.

For more information about the Canadian Health Measures Survey, 2007 to 2009, or to enquire about the concepts, methods or data quality of this release, contact Media Relations (613-951-4636), Communications and Library Services Division.

http://www.statcan.gc.ca/daily-quotidien/100816/dq100816a-eng.htm

Advertisements